PRP Treatment and Lichen Sclerosus

Lichen sclerosus is a chronic condition that causes thin, white patches of skin that look pale or crinkled, usually in the genital (vulvar or anal) area. It can cause pain and discomfort, itching, and easy bruising or tearing of the skin. It often causes permanent scarring. 4% of women with this condition go on to develop vulvar cancer.

Skin affected by lichen sclerosus can also scar and join up with nearby skin. This can change the structure of your vulva – for example, your labia minora may appear flattened, your clitoris can become buried under its hood, and/or the opening of your vagina may shrink. This can sometimes affect your ability to have and/or enjoy sex.

Lichen sclerosus is thought to be related to genetics, immune disorders, trauma, or infection. Traditional treatment is usually topical corticosteroid ointments or creams used to reduce itching and complications, however, there is no documented cure.

"Platelet-rich plasma (PRP), a regenerative medicine, may be a treatment option for women with LS, especially for those of reproductive age. Platelets are involved in both hard- and soft-tissue repair. They provide the essential growth factors involved in stem cell migration, differentiation, and proliferation: fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF). The stimulation of fibroblasts and endothelial cells induces new deposition of extracellular matrix and neovascularization. …PRP leads to complete regeneration of the LS lesion, and consequently to improved quality of life."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960026/